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KMID : 0358420140570030223
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Korean Journal of Obstetrics and Gynecology
2014 Volume.57 No. 3 p.223 ~ p.227
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A meningomyelocele with normal intracranial signs on ultrasound and false-negative amniotic fluid alpha-fetoprotein and acetylcholinesterase
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Yoon Chong-Hyeok
Kang Sang-Kyu
Jin Chan-Hee
Park Moon-Sun
Rho Jeong-Hoon
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Abstract
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Neural tube defects are the major targets of prenatal diagnoses, along with Down syndrome. Prenatal diagnosis of spina bifida is possible at second trimester of gestation through α-fetoprotein and acetylcholinesterase biochemistry assays and ultrasound. In particular, the discovery of characteristic intracranial signs on ultrasound leads to a very high diagnosis rate. However, it is rare for spina bifida to present without intracranial signs while also showing normal values of maternal serum α-fetoprotein, amniotic fluid α-fetoprotein, and acetylcholinesterase. In our hospital, a fetus with spina bifida was delivered at 37+5 weeks’ gestation by cesarean section, and was continually followed up over 2 years to date.
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KEYWORD
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Intracranial sign, Meningocele, Meningocele repair, Maternal serum alpha-fetoproteins, Spinal dysraphism
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